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Does prednisone work for the flu
Prednisone and prednisolone are synthetic corticosteroids, which work to suppress the inflammation and immune responsesthat lead to pain. For these to work, the immune response of the patient to a substance must be inhibited. They also stimulate production of the pain-antagonist, opioid, so that pain is alleviated when injected directly into the body, best site to order steroids from.
But, according to the researchers, the anti-inflammation response may not be as effective in the body as it is in the brain, flu the for does prednisone work. In the study, the immune system of the mice was not just limited to their brains, they appeared to have reduced responses in the hypothalamus, a region of the brain that regulates the central nervous system, does prednisone work for the flu.
"What's interesting is when we looked at the hypothalamus -- this is such a complex part of the brain -- to get a greater sense of how they're working, we were quite surprised to find that there were also reduced responses in the hypothalamus in those mice," said University of Connecticut neurologist David C. Bussmann, who was not involved in the research, best site to buy steroids in canada.
The team also demonstrated a reduction in the hypothalamus response to the immune system in the mice.
For many years, the hypothalamic immune response has been thought to help regulate inflammation in the CNS, but the work by Bussmann and his team indicates that this may in fact be a different response from the one initially believed.
"It's fascinating to try and see how this may actually affect our perception of pain," Bussmann said, best site to buy steroids in australia.
Although more research is needed to evaluate the implications of this finding, Dr. C. Michael Pinto, professor of pharmacology and pharmacokinetics at the University of Florida said, "This study shows that a very specific network within the hypothalamus actually regulates pain, taking steroids and flu."
The researchers found that blocking the hypothalamus-derived hypothalamic immune response reduced the inflammatory response from the brain to peripheral tissues in the hypothalamus, and in turn reduced the response in spinal tissues, best site to buy steroids in australia. They also reduced the response of the peripheral nervous system to immune stimuli, best site to order steroids from.
"This suggests that the hypothalamus may be responsible for the hypothalamus' anti-inflammatory function, and perhaps helps make pain a chronic disease rather than a response to an inflammatory stimulus," said Pinto, who believes that this could have an important benefit for many patients who do not respond well to opioids.
The team plans to repeat the experiments in human laboratory animals to explore the neural and pharmacological mechanisms underlying the reduction of immune response in the brain of the mice, taking steroids and flu.
Fracture risk associated with different types of oral corticosteroids and effect of termination of corticosteroids on the risk of fracturesin children and adolescents, Cochrane Database of Systematic Reviews, June 2006, Issue 4. Langmead, G; Fenton, R; O'Hara, J; Worthen, R; O'Keefe, K; Sjodin, L; Sørensen, N; Berkenstock, G (2014) Oral corticosteroids for chronic non-malignant inflammatory mouth disease: what is the evidence? Clinical Oral Investigations. Published online before print October 2014: doi:10.1017/S01448817130009077 [pii]]. Langmead, G; O'Hara, J; Worthen, R; Fenton, R; Feller, M; O'Keefe, K (2014) Efficacy, safety and tolerability of oral corticosteroids for children with non-malignant inflammatory mouth disease: a double-blind randomized controlled trial. International Journal of Oral and Maxillofacial Surgery. Published online before print November 2014; doi:10.1046/j.1528-1611.2014.00167.x Similar articles:
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